Molecular Mechanism of Inhibition of Survivin Transcription by the GC-rich Sequence-selective DNA Binding Antitumor Agent, Hedamycin: EVIDENCE OF SURVIVIN DOWN-REGULATION ASSOCIATED WITH DRUG SENSITIVITY

Expression of the antiapoptotic protein survivin is associated with cancer cell viability and drug resistance. Thus, control of its expression in cancer cells has significant consequences for cancer therapeutics. Here we have shown that hedamycin, a GC-rich DNA binding drug, down-regulated survivin...

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Detalhes bibliográficos
Main Authors: Wu, Jianguo, Ling, Xiang, Pan, Dalin, Apontes, Pasha, Song, Lei, Liang, Ping, Altieri, Dario C., Beerman, Terry, Li, Fengzhi
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826138/
https://ncbi.nlm.nih.gov/pubmed/15637054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M409350200
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