Molecular Mechanism of Inhibition of Survivin Transcription by the GC-rich Sequence-selective DNA Binding Antitumor Agent, Hedamycin: EVIDENCE OF SURVIVIN DOWN-REGULATION ASSOCIATED WITH DRUG SENSITIVITY

Expression of the antiapoptotic protein survivin is associated with cancer cell viability and drug resistance. Thus, control of its expression in cancer cells has significant consequences for cancer therapeutics. Here we have shown that hedamycin, a GC-rich DNA binding drug, down-regulated survivin...

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Détails bibliographiques
Auteurs principaux: Wu, Jianguo, Ling, Xiang, Pan, Dalin, Apontes, Pasha, Song, Lei, Liang, Ping, Altieri, Dario C., Beerman, Terry, Li, Fengzhi
Format: Artigo
Langue:Inglês
Publié: 2005
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826138/
https://ncbi.nlm.nih.gov/pubmed/15637054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M409350200
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