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A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches.

G.T mispairs, the sole mismatch type that can arise in "resting" mammalian DNA (through spontaneous hydrolytic deamination of 5-methylcytosine), are corrected in vivo with high efficiency and mostly to a G.C. We identified a protein factor, present in HeLa cell extracts, that binds selecti...

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Autori principali: Jiricny, J, Hughes, M, Corman, N, Rudkin, B B
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1988
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC282606/
https://ncbi.nlm.nih.gov/pubmed/3194394
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