Elucidation of the Pharmacokinetic/Pharmacodynamic Determinant of Colistin Activity against Pseudomonas aeruginosa in Murine Thigh and Lung Infection Models

Colistin is increasingly used as last-line therapy against Gram-negative pathogens. The pharmacokinetic (PK)/pharmacodynamic (PD) index that best correlates with the efficacy of colistin remains undefined. The activity of colistin against three strains of Pseudomonas aeruginosa was studied in neutro...

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Autores principales: Dudhani, Rajesh V., Turnidge, John D., Coulthard, Kingsley, Milne, Robert W., Rayner, Craig R., Li, Jian, Nation, Roger L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826009/
https://ncbi.nlm.nih.gov/pubmed/20028824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01114-09
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