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Rates and Mechanisms of Resistance Development in Mycobacterium tuberculosis to a Novel Diarylquinoline ATP Synthase Inhibitor

R207910 (also known as TMC207) is an investigational drug currently in clinical studies for the treatment of multidrug-resistant (MDR) tuberculosis. It has a high degree of antimycobacterial activity and is equally effective against drug-susceptible and MDR Mycobacterium tuberculosis isolates. In th...

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Main Authors: Huitric, E., Verhasselt, P., Koul, A., Andries, K., Hoffner, S., Andersson, D. I.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825986/
https://ncbi.nlm.nih.gov/pubmed/20038615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01611-09
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