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In Vitro Antimycobacterial Spectrum of a Diarylquinoline ATP Synthase Inhibitor

The diarylquinoline R207910 is in clinical development for tuberculosis treatment. The MIC(50) for 41 drug-susceptible and 44 multidrug-resistant Mycobacterium tuberculosis clinical isolates was 0.032 μg/ml. Out of 20 additional mycobacterial species, three were found to be naturally resistant to R2...

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Detalhes bibliográficos
Main Authors: Huitric, Emma, Verhasselt, Peter, Andries, Koen, Hoffner, Sven E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151410/
https://ncbi.nlm.nih.gov/pubmed/17709466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00181-07
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