Evaluation of New Thiazolide/Thiadiazolide Derivatives Reveals Nitro Group-Independent Efficacy against In Vitro Development of Cryptosporidium parvum

Thirty-nine new thiazolide/thiadiazolide compounds were compared with the nitrothiazole nitazoxanide for activity against Cryptosporidium parvum development in HCT-8 cells. Twenty-seven agents exerted ≥90% inhibition. Agents with a lower 50% inhibitory concentration (IC(50)) than nitazoxanide were e...

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Autors principals: Gargala, Gilles, Le Goff, Laetitia, Ballet, Jean-Jacques, Favennec, Loic, Stachulski, Andrew V., Rossignol, Jean-François
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825981/
https://ncbi.nlm.nih.gov/pubmed/20047919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00614-09
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