Pharmacokinetics of Acyclovir and Its Metabolites in Cerebrospinal Fluid and Systemic Circulation after Administration of High-Dose Valacyclovir in Subjects with Normal and Impaired Renal Function

Valacyclovir, the l-valyl ester prodrug of acyclovir (ACV), is widely prescribed to treat infections caused by varicella-zoster virus or herpes simplex virus. Rarely, treatment is complicated by reversible neuropsychiatric symptoms. By mechanisms not fully understood, this occurs more frequently in...

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Detalhes bibliográficos
Principais autores: Smith, James P., Weller, Stephen, Johnson, Benjamin, Nicotera, Janet, Luther, James M., Haas, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825963/
https://ncbi.nlm.nih.gov/pubmed/20038622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00729-09
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