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Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines
We studied the biochemical mechanisms associated with inhibition and resistance to a 4,5-dihydroxypyrimidine carboxylate that inhibits the hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B. On the basis of the structure of the pharmacophore, it has been suggested that these compounds may act...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2825958/ https://ncbi.nlm.nih.gov/pubmed/20028820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01216-09 |
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