Downregulation of PU.1 Leads to Decreased Expression of Dectin-1 in Alveolar Macrophages during Pneumocystis Pneumonia

Dectin-1 is an important macrophage phagocytic receptor recognizing fungal β-glucans. In this study, the mRNA levels of the Dectin-1 gene were found to be decreased by 61% in alveolar macrophages (AMs) from Pneumocystis-infected mice. The expression of Dectin-1 protein on the surface of these cells...

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Autori principali: Zhang, Chen, Wang, Shao-Hung, Liao, Chung-Ping, Shao, Shoujin, Lasbury, Mark E., Durant, Pamela J., Lee, Chao-Hung
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
Soggetti:
Fungal and Parasitic Infections
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825957/
https://ncbi.nlm.nih.gov/pubmed/20065023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01141-09
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