Phosphoinositide 3-Kinase γ Gene Knockout Impairs Postischemic Neovascularization and Endothelial Progenitor Cell Functions

OBJECTIVE: We evaluated whether phosphatidylinositol 3-kinase γ (PI3Kγ) plays a role in reparative neovascularization and endothelial progenitor cell (EPC) function. METHODS AND RESULTS: Unilateral limb ischemia was induced in mice lacking the PI3Kγ gene (PI3Kγ(−/−)) or expressing a catalytically in...

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Bibliografische gegevens
Hoofdauteurs: Madeddu, Paolo, Kraenkel, Nicolle, Barcelos, Luciola S., Siragusa, Mauro, Campagnolo, Paola, Oikawa, Atsuhiko, Caporali, Andrea, Herman, Andrew, Azzolino, Ornella, Barberis, Laura, Perino, Alessia, Damilano, Federico, Emanueli, Costanza, Hirsch, Emilio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825808/
https://ncbi.nlm.nih.gov/pubmed/17962628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.107.145573
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