Rescue of cardiomyopathy in PPARα transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and PPARα activators

BACKGROUND: Emerging evidence in obesity and diabetes demonstrates that excessive myocardial fatty acid (FA) uptake and oxidation contribute to cardiac dysfunction. Transgenic mice with cardiac-specific overexpression of the FA-activated nuclear receptor PPARα (MHC-PPARα mice) exhibit phenotypic fea...

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Autori principali: Duncan, Jennifer G., Bharadwaj, Kalyani G., Fong, Juliet L., Mitra, Riddhi, Sambandam, Nandakumar, Courtois, Michael R., Lavine, Kory J., Goldberg, Ira J., Kelly, Daniel P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825753/
https://ncbi.nlm.nih.gov/pubmed/20065164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.888735
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