Characterization and Structural Studies of the Plasmodium falciparum Ubiquitin and Nedd8 Hydrolase UCHL3

Like their human hosts, Plasmodium falciparum parasites rely on the ubiquitin-proteasome system for survival. We previously identified PfUCHL3, a deubiquitinating enzyme, and here we characterize its activity and changes in active site architecture upon binding to ubiquitin. We find strong evidence...

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Main Authors: Artavanis-Tsakonas, Katerina, Weihofen, Wilhelm A., Antos, John M., Coleman, Bradley I., Comeaux, Christy A., Duraisingh, Manoj T., Gaudet, Rachelle, Ploegh, Hidde L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825479/
https://ncbi.nlm.nih.gov/pubmed/20042598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.072405
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