Structure of GroEL in Complex with an Early Folding Intermediate of Alanine Glyoxylate Aminotransferase

Primary hyperoxaluria type 1 is a rare autosomal recessive disease caused by mutations in the alanine glyoxylate aminotransferase gene (AGXT). We have previously shown that P11L and I340M polymorphisms together with I244T mutation (AGXT-LTM) represent a conformational disease that could be amenable...

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Hlavní autoři: Albert, Armando, Yunta, Cristina, Arranz, Rocío, Peña, Álvaro, Salido, Eduardo, Valpuesta, José María, Martín-Benito, Jaime
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825432/
https://ncbi.nlm.nih.gov/pubmed/20056599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.062471
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