Striatal overexpression of ΔJunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease

BACKGROUND: Involuntary movements, or dyskinesia, represent a debilitating complication of dopamine replacement therapy for Parkinson disease (PD). The transcription factor ΔFosB accumulates in the denervated striatum and dimerizes primarily with JunD upon repeated L-DOPA administration. Previous st...

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Main Authors: Berton, Olivier, Guigoni, Céline, Li, Qin, Bioulac, Bernard H., Aubert, Incarnation, Gross, Christian E., DiLeone, Ralph J., Nestler, Eric J., Bezard, Erwan
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825375/
https://ncbi.nlm.nih.gov/pubmed/19481198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2009.04.005
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