PCA-based bootstrap confidence interval tests for gene-disease association involving multiple SNPs

BACKGROUND: Genetic association study is currently the primary vehicle for identification and characterization of disease-predisposing variant(s) which usually involves multiple single-nucleotide polymorphisms (SNPs) available. However, SNP-wise association tests raise concerns over multiple testing...

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Autors principals: Peng, Qianqian, Zhao, Jinghua, Xue, Fuzhong
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Methodology article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825231/
https://ncbi.nlm.nih.gov/pubmed/20100356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2156-11-6
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