Alpha-Synuclein Disrupted Dopamine Homeostasis Leads to Dopaminergic Neuron Degeneration in Caenorhabditis elegans

Disruption of dopamine homeostasis may lead to dopaminergic neuron degeneration, a proposed explanation for the specific vulnerability of dopaminergic neurons in Parkinson's disease. While expression of human α-synuclein in C. elegans results in dopaminergic neuron degeneration, the effects of...

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Autors principals: Cao, Pengxiu, Yuan, Yiyuan, Pehek, Elizabeth A., Moise, Alex R., Huang, Ying, Palczewski, Krzysztof, Feng, Zhaoyang
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824852/
https://ncbi.nlm.nih.gov/pubmed/20174477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009312
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