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Roles of Electrostatics and Conformation in Protein-Crystal Interactions

In vitro studies have shown that the phosphoprotein osteopontin (OPN) inhibits the nucleation and growth of hydroxyapatite (HA) and other biominerals. In vivo, OPN is believed to prevent the calcification of soft tissues. However, the nature of the interaction between OPN and HA is not understood. I...

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Detalhes bibliográficos
Main Authors: Azzopardi, Paul V., O'Young, Jason, Lajoie, Gilles, Karttunen, Mikko, Goldberg, Harvey A., Hunter, Graeme K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824833/
https://ncbi.nlm.nih.gov/pubmed/20174473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009330
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