In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(ε-caprolactone) scaffolds

Three-dimensionally woven poly(ε-caprolactone)(PCL) scaffolds were combined with adult human mesenchymal stem cells (hMSC) to engineer mechanically functional cartilage constructs in vitro. The specific objectives were to: (i) produce PCL scaffolds with cartilage-like mechanical properties, (ii) dem...

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Bibliographic Details
Main Authors: Valonen, P.K., Moutos, F.T., Kusanagi, A., Moretti, M., Diekman, B.O., Welter, J.F., Caplan, A.I., Guilak, F., Freed, L.E.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824534/
https://ncbi.nlm.nih.gov/pubmed/20034665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2009.11.092
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