Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation

The human cytomegalovirus glycoprotein US2 induces dislocation of MHC class I heavy chains from the endoplasmic reticulum (ER) into the cytosol and targets them for proteasomal degradation. Signal peptide peptidase (SPP) has been shown to be integral for US2-induced dislocation of MHC class I heavy...

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Bibliographic Details
Main Authors: Lee, Seong-Ok, Cho, Kwangmin, Cho, Sunglim, Kim, Ilkwon, Oh, Changhoon, Ahn, Kwangseog
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824452/
https://ncbi.nlm.nih.gov/pubmed/19942855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.359
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