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Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues
Cells often mount ultrasensitive (switch-like) responses to stimuli. The design principles underlying many switches are not known. We computationally studied the switching behavior of GTPases, and found that this first-order kinetic system can show ultrasensitivity. Analytical solutions indicate tha...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824311/ https://ncbi.nlm.nih.gov/pubmed/20080566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908647107 |
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