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Label-free microarray imaging for direct detection of DNA hybridization and single-nucleotide mismatches
A novel method is proposed for direct detection of DNA hybridization on microarrays. Optical interferometry is used for label-free sensing of biomolecular accumulation on glass surfaces, enabling dynamic detection of interactions. Capabilities of the presented method are demonstrated by high-through...
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| Asıl Yazarlar: | , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824047/ https://ncbi.nlm.nih.gov/pubmed/20097056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bios.2009.12.032 |
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