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Wnt-5a occludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons
BACKGROUND: Soluble amyloid-β (Aβ;) oligomers have been recognized to be early and key intermediates in Alzheimer's disease (AD)-related synaptic dysfunction. Aβ oligomers block hippocampal long-term potentiation (LTP) and impair rodent spatial memory. Wnt signaling plays an important role in n...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2823745/ https://ncbi.nlm.nih.gov/pubmed/20205789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-3 |
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