Wnt-5a occludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons

BACKGROUND: Soluble amyloid-β (Aβ;) oligomers have been recognized to be early and key intermediates in Alzheimer's disease (AD)-related synaptic dysfunction. Aβ oligomers block hippocampal long-term potentiation (LTP) and impair rodent spatial memory. Wnt signaling plays an important role in n...

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Main Authors: Cerpa, Waldo, Farías, Ginny G, Godoy, Juan A, Fuenzalida, Marco, Bonansco, Christian, Inestrosa, Nibaldo C
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823745/
https://ncbi.nlm.nih.gov/pubmed/20205789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-3
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