The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model

BACKGROUND: Pin 1 is a peptidyl-prolyl isomerase inhibitor related to cyclophilin A and FK506 binding protein (FKBP). Juglone (5-hydroxy-1,4-naphthoquinone) is a natural inhibitor of Pin 1 with anti-inflammatory and antifibrotic properties. We evaluated the role of Pin 1 in renal fibrogenesis by eva...

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Autors principals: Reese, Shannon, Vidyasagar, Aparna, Jacobson, Lynn, Acun, Zeki, Esnault, Stephane, Hullett, Debra, Malter, James S, Djamali, Arjang
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823698/
https://ncbi.nlm.nih.gov/pubmed/20047646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-1536-3-1
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