Catalytic Mechanism of Human α-Galactosidase

The enzyme α-galactosidase (α-GAL, also known as α-GAL A; E.C. 3.2.1.22) is responsible for the breakdown of α-galactosides in the lysosome. Defects in human α-GAL lead to the development of Fabry disease, a lysosomal storage disorder characterized by the buildup of α-galactosylated substrates in th...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Guce, Abigail I., Clark, Nathaniel E., Salgado, Eric N., Ivanen, Dina R., Kulminskaya, Anna A., Brumer, Harry, Garman, Scott C.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2010
Θέματα:
Enzyme Catalysis and Regulation
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823503/
https://ncbi.nlm.nih.gov/pubmed/19940122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.060145
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