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Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure

BACKGROUND: Cardiac cachexia is characterized by an exaggerated loss of skeletal muscle, weakness, and exercise intolerance, although the etiology of these effects remains unknown. Here we hypothesized that the heart functions as an endocrine organ in promoting systemic cachexia by secreting peptide...

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Autors principals: Heineke, Joerg, Auger-Messier, Mannix, Xu, Jian, Sargent, Michelle, York, Allen, Welle, Stephen, Molkentin, Jeffery D.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823256/
https://ncbi.nlm.nih.gov/pubmed/20065166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.882068
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