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Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity

BACKGROUND: Neuropilin-1 (NRP1) is a non-tyrosine kinase receptor for vascular endothelial growth factor (VEGF) recently implicated in tumour functions. METHODS: In this study we used a specific antagonist of VEGF binding to the NRP1 b1 domain, EG3287, to investigate the functional roles of NRP1 in...

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Detalhes bibliográficos
Main Authors: Jia, H, Cheng, L, Tickner, M, Bagherzadeh, A, Selwood, D, Zachary, I
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822953/
https://ncbi.nlm.nih.gov/pubmed/20087344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605539
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