Combination therapy: intermittent sorafenib with bevacizumab yields activity and decreased toxicity

BACKGROUND: We previously reported preliminary results of our phase I study of continuous daily sorafenib with bevacizumab every other week for solid tumours. Toxicity was moderate, leading to additional dose levels (DL) testing intermittent sorafenib dosing. METHODS: Seventeen patients with advance...

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Detalhes bibliográficos
Main Authors: Lee, J-M, Sarosy, G A, Annunziata, C M, Azad, N, Minasian, L, Kotz, H, Squires, J, Houston, N, Kohn, E C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822947/
https://ncbi.nlm.nih.gov/pubmed/20051952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605514
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