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Glycosidase inhibition: assessing mimicry of the transition state

Glycoside hydrolases, the enzymes responsible for hydrolysis of the glycosidic bond in di-, oligo- and polysaccharides, and glycoconjugates, are ubiquitous in Nature and fundamental to existence. The extreme stability of the glycosidic bond has meant these enzymes have evolved into highly proficient...

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Detalhes bibliográficos
Main Authors: Gloster, Tracey M., Davies, Gideon J.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822703/
https://ncbi.nlm.nih.gov/pubmed/20066263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b915870g
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