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Persistent Mitochondrial Damage by Nitric Oxide and its Derivatives: Neuropathological Implications
Approximately 15 years ago we reported that cytochrome c oxidase (CcO) was persistently inhibited as a consequence of endogenous induction and activation of nitric oxide ((•)NO) synthase-2 (NOS2) in astrocytes. Furthermore, the reactive nitrogen species implicated was peroxynitrite. In contrast to t...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Research Foundation
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2822548/ https://ncbi.nlm.nih.gov/pubmed/20162100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/neuro.14.001.2010 |
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