Inhibition of Thromboxane Synthase Activity Improves Glioblastoma Response to Alkylation Chemotherapy

Thromboxane synthase (TXSA), an enzyme of the arachidonic acid metabolism, is upregulated in human glial tumors and is involved in glioma progression. Here, we analyzed the in vitro and in vivo effects of pharmacological inhibition of TXSA activity on human glioblastoma cells. Furegrelate, a specifi...

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Bibliografiske detaljer
Main Authors: Schmidt, Nils Ole, Ziu, Mateo, Cargioli, Theresa, Westphal, Manfred, Giese, Alf, Black, Peter M, Carroll, Rona S
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press Inc. 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822453/
https://ncbi.nlm.nih.gov/pubmed/20165694
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