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Inhibition of Thromboxane Synthase Activity Improves Glioblastoma Response to Alkylation Chemotherapy

Thromboxane synthase (TXSA), an enzyme of the arachidonic acid metabolism, is upregulated in human glial tumors and is involved in glioma progression. Here, we analyzed the in vitro and in vivo effects of pharmacological inhibition of TXSA activity on human glioblastoma cells. Furegrelate, a specifi...

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Détails bibliographiques
Auteurs principaux: Schmidt, Nils Ole, Ziu, Mateo, Cargioli, Theresa, Westphal, Manfred, Giese, Alf, Black, Peter M, Carroll, Rona S
Format: Artigo
Langue:Inglês
Publié: Neoplasia Press Inc. 2010
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822453/
https://ncbi.nlm.nih.gov/pubmed/20165694
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