Breast Cancer-associated Fibroblasts Confer AKT1-mediated Epigenetic Silencing of Cystatin M in Epithelial Cells

The interplay between histone modifications and promoter hypermethylation provides a causative explanation for epigenetic gene silencing in cancer. Less is known about the upstream initiators that direct this process. Here, we report that the Cystatin M (CST6) tumor suppressor gene is concurrently d...

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Bibliografiske detaljer
Main Authors: Lin, Huey-Jen L., Zuo, Tao, Lin, Ching-Hung, Kuo, Chieh Ti, Liyanarachchi, Sandya, Sun, Shuying, Shen, Rulong, Deatherage, Daniel E., Potter, Dustin, Asamoto, Lisa, Lin, Shili, Yan, Pearlly S., Cheng, Ann-Lii, Ostrowski, Michael C., Huang, Tim H.-M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821873/
https://ncbi.nlm.nih.gov/pubmed/19074894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0288
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