Early Neural and Vascular Dysfunctions in Diabetic Rats Are Largely Sequelae of Increased Sorbitol Oxidation

These experiments were undertaken to assess the importance of cytoplasmic (c) sorbitol oxidation versus mitochondrial (m) pyruvate oxidation in mediating neural and vascular dysfunction attributable to hyperglycemia in diabetic rats. Increased oxidation of sorbitol is coupled to enzymatic reduction...

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Detalhes bibliográficos
Main Authors: Ido, Yasuo, Nyengaard, Jens R., Chang, Kathy, Tilton, Ronald G., Kilo, Charles, Mylari, Banavara L., Oates, Peter J., Williamson, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2010
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821145/
https://ncbi.nlm.nih.gov/pubmed/19624259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2009.2502
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