Complement Component C1q Mediates Mitochondria-Driven Oxidative Stress in Neonatal Hypoxic–Ischemic Brain Injury

Hypoxic–ischemic (HI) brain injury in infants is a leading cause of lifelong disability. We report a novel pathway mediating oxidative brain injury after hypoxia–ischemia in which C1q plays a central role. Neonatal mice incapable of classical or terminal complement activation because of C1q or C6 de...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Ten, Vadim S., Yao, Jun, Ratner, Veniamin, Sosunov, Sergey, Fraser, Deborah A., Botto, Marina, Sivasankar, Baalasubramanian, Morgan, B. Paul, Silverstein, Samuel, Stark, Raymond, Polin, Richard, Vannucci, Susan J., Pinsky, David, Starkov, Anatoly A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2010
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821109/
https://ncbi.nlm.nih.gov/pubmed/20147536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5249-09.2010
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky