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The Histone Deacetylase SIRT6 Regulates Glucose Homeostasis via Hif1α
SIRT6 is a member of a highly conserved family of NAD(+)-dependent deacetylases with various roles in metabolism, stress resistance and lifespan. SIRT6 deficient mice develop normally but succumb to a lethal hypoglycemia early in life; however, the mechanism underlying this hypoglycemia remained unc...
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| 主要な著者: | , , , , , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2821045/ https://ncbi.nlm.nih.gov/pubmed/20141841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.12.041 |
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