The Histone Deacetylase SIRT6 Regulates Glucose Homeostasis via Hif1α

SIRT6 is a member of a highly conserved family of NAD(+)-dependent deacetylases with various roles in metabolism, stress resistance and lifespan. SIRT6 deficient mice develop normally but succumb to a lethal hypoglycemia early in life; however, the mechanism underlying this hypoglycemia remained unc...

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Main Authors: Zhong, Lei, D'Urso, Agustina, Toiber, Debra, Sebastian, Carlos, Henry, Ryan E., Vadysirisack, Douangsone D., Guimaraes, Alexander, Marinelli, Brett, Wikstrom, Jakob D., Nir, Tomer, Clish, Clary B., Vaitheesvaran, Bhavapriya, Iliopoulos, Othon, Kurland, Irwin, Dor, Yuval, Weissleder, Ralph, Shirihai, Orian S., Ellisen, Leif W., Espinosa, Joaquin M., Mostoslavsky, Raul
פורמט: Artigo
שפה:Inglês
יצא לאור: 2010
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821045/
https://ncbi.nlm.nih.gov/pubmed/20141841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.12.041
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