INHIBITION OF ACETYLCHOLINESTERASE BY CHROMOPHORE-LINKED FLUOROPHOSPHONATES

Fluorophosphonate (FP) head groups were tethered to a variety of chromophores (C) via a triazole group and tested as FPC inhibitors of recombinant mouse (rMoAChE) and electric eel (EEAChE) acetylcholinesterase. The inhibitors showed bimolecular inhibition constants (k(i)) ranging from 0.3 × 10(5) M(...

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Detalhes bibliográficos
Main Authors: Guo, Lilu, Suarez, Alirica I., Braden, Michael R., Gerdes, John M., Thompson, Charles M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821040/
https://ncbi.nlm.nih.gov/pubmed/20034789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.12.007
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