Human CD133(+) Progenitor Cells Promote the Healing of Diabetic Ischemic Ulcers by Paracrine Stimulation of Angiogenesis and Activation of Wnt Signaling

We evaluated the healing potential of human fetal aorta–derived CD133(+) progenitor cells and their conditioned medium (CD133(+) CCM) in a new model of ischemic diabetic ulcer. Streptozotocin-induced diabetic mice underwent bilateral limb ischemia and wounding. One wound was covered with collagen co...

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Hauptverfasser: Barcelos, Lucíola S., Duplaa, Cécile, Kränkel, Nicolle, Graiani, Gallia, Invernici, Gloria, Katare, Rajesh, Siragusa, Mauro, Meloni, Marco, Campesi, Ilaria, Monica, Manuela, Simm, Andreas, Campagnolo, Paola, Mangialardi, Giuseppe, Stevanato, Lara, Alessandri, Giulio, Emanueli, Costanza, Madeddu, Paolo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821014/
https://ncbi.nlm.nih.gov/pubmed/19342601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.192138
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