Multi-Low-Dose Mucosal Simian Immunodeficiency Virus SIVmac239 Challenge of Cynomolgus Macaques Immunized with “Hyperattenuated” SIV Constructs

Hyperattenuated simian immunodeficiency virus SIVmac239-derived constructs Δ5-CMV and Δ6-CCI are an effort to render SIV incapable of, in practical terms, both reversion and recombination while maintaining the immune features of SIV as a retrovirus. Primary inoculation of cynomolgus macaques with 10...

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Bibliographic Details
Main Authors: Willer, David O., Guan, Yongjun, Luscher, Mark A., Li, Bing, Pilon, Rick, Fournier, Jocelyn, Parenteau, Monique, Wainberg, Mark A., Sandstrom, Paul, MacDonald, Kelly S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820907/
https://ncbi.nlm.nih.gov/pubmed/20032177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01995-09
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