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The Fic domain: A new paradigm for adenylylation
We show that the secreted antigen, IbpA, of the respiratory pathogen Histophilus somni induces cytotoxicity in mammalian cells via its Fic domains. Fic domains are defined by a core HPFxxGNGR motif and are conserved from bacteria to humans. We demonstrate that the Fic domains of IbpA catalyze a uniq...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2820730/ https://ncbi.nlm.nih.gov/pubmed/19362538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.03.008 |
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