The Fic domain: A new paradigm for adenylylation

We show that the secreted antigen, IbpA, of the respiratory pathogen Histophilus somni induces cytotoxicity in mammalian cells via its Fic domains. Fic domains are defined by a core HPFxxGNGR motif and are conserved from bacteria to humans. We demonstrate that the Fic domains of IbpA catalyze a uniq...

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Hlavní autoři: Worby, Carolyn A., Mattoo, Seema, Kruger, Robert P., Corbeil, Lynette B., Koller, Antonius, Mendez, Juan C., Zekarias, Bereket, Lazar, Cheri, Dixon, Jack E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820730/
https://ncbi.nlm.nih.gov/pubmed/19362538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.03.008
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