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Activity and Cellular Localization of an Oncogenic Glioblastoma Multiforme-associated EGF Receptor Mutant Possessing a Duplicated Kinase Domain
A mutation of the epidermal growth factor receptor (EGFR) that results in a tandem kinase domain duplication (TKD-EGFR) has been described in glioblastoma multiforme biopsies and cell lines. Although the TKD-EGFR confers tumorigenicity, little is known about the molecular underpinnings of receptor d...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2820599/ https://ncbi.nlm.nih.gov/pubmed/19915609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.385 |
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