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Impaired Clearance of Methotrexate in Organic Anion Transporter 3 (Slc22a8) Knockout Mice: A Gender Specific Impact of Reduced Folates
PURPOSE: To elucidate the role of the renal basolateral transporter, Oat3, in the disposition of methotrexate. MATERIALS AND METHODS: Chinese hamster ovary cells expressing mouse Oat3 were used to determine kinetics and specificity of inhibition of methotrexate transport. Methotrexate clearance was...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2820254/ https://ncbi.nlm.nih.gov/pubmed/17660957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-007-9407-0 |
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