Effect of dose-escalation of 5-fluorouracil on circadian variability of its pharmacokinetics in Japanese patients with Stage III/IVa esophageal squamous cell carcinoma

Objective: The effects of dose-escalation of 5-fluorouracil (5-FU) on the clinical outcome and pharmacokinetics of 5-FU were investigated in Japanese patients with Stage III/IVa esophageal squamous cell carcinoma. Methods: Thirty-five patients with Stage III/IVa were enrolled, who were treated with...

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Hauptverfasser: Kuwahara, Akiko, Yamamori, Motohiro, Nishiguchi, Kohshi, Okuno, Tatsuya, Chayahara, Naoko, Miki, Ikuya, Tamura, Takao, Kadoyama, Kaori, Inokuma, Tsubasa, Takemoto, Yoshiji, Nakamura, Tsutomu, Kataoka, Kazusaburo, Sakaeda, Toshiyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2010
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820235/
https://ncbi.nlm.nih.gov/pubmed/20151048
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