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Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K-562 leukemia cells.

Tiazofurin (2-beta-D-ribofuranosyl-4-thiazole-carboxamide; NSC 286193), an antitumor carbon-linked nucleoside that inhibits IMP dehydrogenase (IMP:NAD+ oxidoreductase; EC 1.1.1.205) and depletes guanylate levels, can activate the erythroid differentiation program of K-562 human leukemia cells. Tiazo...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Olah, E, Natsumeda, Y, Ikegami, T, Kote, Z, Horanyi, M, Szelenyi, J, Paulik, E, Kremmer, T, Hollan, S R, Sugar, J
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1988
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282007/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2901100/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.17.6533
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