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Differential binding patterns of monoclonal antibody 2C4 to the ErbB3–p185(her2/neu) and the EGFR–p185(her2/neu) complexes

2C4 (Pertuzumab, Omnitarg) is a monoclonal antibody targeting p185(her2/neu), which is overexpressed in 30% of invasive breast cancer. 2C4 is currently in phase II clinical trials for several types of cancers. This antibody has been reported to disrupt the association between p185(her2/neu) and ErbB...

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Sonraí Bibleagrafaíochta
Main Authors: Cai, Z, Zhang, G, Zhou, Z, Bembas, K, Drebin, JA, Greene, MI, Zhang, H
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819401/
https://ncbi.nlm.nih.gov/pubmed/18264138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.13
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