Collagenolytic Activity is Suppressed in Organ-Cultured Human Skin Exposed to a Gadolinium-Based MRI Contrast Agent

OBJECTIVE: Human skin produces increased amounts of matrix metalloproteinase-1 (MMP-1) when exposed in organ culture to Omniscan, one of the gadolinium-based MRI contrast agents (GBCA). MMP-1, by virtue of its ability to degrade structural collagen, contributes to collagen turnover in the skin. The...

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Hlavní autoři: Perone, Patricia A., Weber, Stephanie L., DaSilva, Marissa, Paruchuri, Tejaswi, Bhagavathula, Narasimharao, Aslam, Muhammad N., Dame, Michael K., Johnson, Kent J., Swartz, Richard D., Varani, James
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819152/
https://ncbi.nlm.nih.gov/pubmed/19996758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/RLI.0b013e3181bf95eb
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