Structural basis for cofactor-independent dioxygenation of N-heteroaromatic compounds at the α/β-hydrolase fold

Enzymatic catalysis of oxygenation reactions in the absence of metal or organic cofactors is a considerable biochemical challenge. The CO-forming 1-H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase (HOD) from Arthrobacter nitroguajacolicus Rü61a and 1-H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase (QDO) from...

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Détails bibliographiques
Auteurs principaux: Steiner, Roberto A., Janssen, Helge J., Roversi, Pietro, Oakley, Aaron J., Fetzner, Susanne
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2010
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818892/
https://ncbi.nlm.nih.gov/pubmed/20080731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909033107
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