Intervening Inhibition Underlies Simple-Cell Receptive Field Structure in Visual Cortex

Synaptic inputs underlying spike receptive fields (RFs) are key to understanding mechanisms for neuronal processing. Here, whole-cell voltage-clamp recordings from neurons in mouse primary visual cortex revealed the spatial patterns of their excitatory and inhibitory synaptic inputs evoked by On and...

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Main Authors: Liu, Bao-hua, Li, Pingyang, Sun, Yujiao J., Li, Ya-tang, Zhang, Li I., Tao, Huizhong Whit
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818750/
https://ncbi.nlm.nih.gov/pubmed/19946318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2443
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spelling pubmed-28187502010-07-01 Intervening Inhibition Underlies Simple-Cell Receptive Field Structure in Visual Cortex Liu, Bao-hua Li, Pingyang Sun, Yujiao J. Li, Ya-tang Zhang, Li I. Tao, Huizhong Whit Nat Neurosci Article Synaptic inputs underlying spike receptive fields (RFs) are key to understanding mechanisms for neuronal processing. Here, whole-cell voltage-clamp recordings from neurons in mouse primary visual cortex revealed the spatial patterns of their excitatory and inhibitory synaptic inputs evoked by On and Off stimuli. Surprisingly, neurons with either segregated or overlapped On/Off spike subfields exhibited substantial overlaps between all the four synaptic subfields. The segregated RF structures are generated by the integration of excitation and inhibition with a stereotypic pattern: the peaks of excitatory On/Off subfields are separated and flank co-localized peaks of inhibitory On/Off subfields. The small mismatch of excitation/inhibition leads to an asymmetric inhibitory shaping of On/Off spatial tunings, resulting in a great enhancement of their distinctiveness. Thus, slightly separated On/Off excitation together with intervening inhibition can create simple-cell RF structure, and the dichotomy of RF structures may arise from a fine-tuning of the spatial arrangement of synaptic inputs. 2009-11-29 2010-01 /pmc/articles/PMC2818750/ /pubmed/19946318 http://dx.doi.org/10.1038/nn.2443 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Article
spellingShingle Article
Liu, Bao-hua
Li, Pingyang
Sun, Yujiao J.
Li, Ya-tang
Zhang, Li I.
Tao, Huizhong Whit
Intervening Inhibition Underlies Simple-Cell Receptive Field Structure in Visual Cortex
description Synaptic inputs underlying spike receptive fields (RFs) are key to understanding mechanisms for neuronal processing. Here, whole-cell voltage-clamp recordings from neurons in mouse primary visual cortex revealed the spatial patterns of their excitatory and inhibitory synaptic inputs evoked by On and Off stimuli. Surprisingly, neurons with either segregated or overlapped On/Off spike subfields exhibited substantial overlaps between all the four synaptic subfields. The segregated RF structures are generated by the integration of excitation and inhibition with a stereotypic pattern: the peaks of excitatory On/Off subfields are separated and flank co-localized peaks of inhibitory On/Off subfields. The small mismatch of excitation/inhibition leads to an asymmetric inhibitory shaping of On/Off spatial tunings, resulting in a great enhancement of their distinctiveness. Thus, slightly separated On/Off excitation together with intervening inhibition can create simple-cell RF structure, and the dichotomy of RF structures may arise from a fine-tuning of the spatial arrangement of synaptic inputs.
author Liu, Bao-hua
Li, Pingyang
Sun, Yujiao J.
Li, Ya-tang
Zhang, Li I.
Tao, Huizhong Whit
author_facet Liu, Bao-hua
Li, Pingyang
Sun, Yujiao J.
Li, Ya-tang
Zhang, Li I.
Tao, Huizhong Whit
author_sort Liu, Bao-hua
title Intervening Inhibition Underlies Simple-Cell Receptive Field Structure in Visual Cortex
title_short Intervening Inhibition Underlies Simple-Cell Receptive Field Structure in Visual Cortex
title_full Intervening Inhibition Underlies Simple-Cell Receptive Field Structure in Visual Cortex
title_fullStr Intervening Inhibition Underlies Simple-Cell Receptive Field Structure in Visual Cortex
title_full_unstemmed Intervening Inhibition Underlies Simple-Cell Receptive Field Structure in Visual Cortex
title_sort intervening inhibition underlies simple-cell receptive field structure in visual cortex
publishDate 2009
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2818750/
https://ncbi.nlm.nih.gov/pubmed/19946318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2443
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