Voxel-based estimation of kinetic model parameters of the L-[1-(11)C]leucine PET method for determination of regional rates of cerebral protein synthesis: Validation and comparison with region-of-interest based methods

We adapted and validated a basis function method (BFM) to estimate at the voxel level parameters of the kinetic model of the L-[1-(11)C]leucine PET method and regional rates of cerebral protein synthesis (rCPS). In simulation at noise levels typical of voxel data, BFM yielded low bias estimates of r...

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Bibliografiska uppgifter
Huvudupphovsmän: Tomasi, Giampaolo, Bertoldo, Alessandra, Bishu, Shrinivas, Unterman, Aaron, Smith, Carolyn Beebe, Schmidt, Kathleen C
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818563/
https://ncbi.nlm.nih.gov/pubmed/19436319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2009.52
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