Phenylbutyric Acid Rescues Endoplasmic Reticulum Stress-Induced Suppression of APP Proteolysis and Prevents Apoptosis in Neuronal Cells

BACKGROUND: The familial and sporadic forms of Alzheimer's disease (AD) have an identical pathology with a severe disparity in the time of onset [1]. The pathological similarity suggests that epigenetic processes may phenocopy the Familial Alzheimer's disease (FAD) mutations within sporadi...

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Detalhes bibliográficos
Main Authors: Wiley, Jesse C., Meabon, James S., Frankowski, Harald, Smith, Elise A., Schecterson, Leslayann C., Bothwell, Mark, Ladiges, Warren C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817752/
https://ncbi.nlm.nih.gov/pubmed/20161760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009135
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