Increased Bone Volume and Correction of HYP Mouse Hypophosphatemia in the Klotho/HYP Mouse

Inactivating mutations of PHEX cause X-linked hypophosphatemia and result in increased circulating fibroblast growth factor 23 (FGF23). FGF23 action is dependent upon Klotho, which converts FGF receptor 1 into an FGF23-specific receptor. Disruption of Klotho results in a complex bone phenotype and h...

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Hlavní autoři: Brownstein, Catherine A., Zhang, Junhui, Stillman, Althea, Ellis, Bruce, Troiano, Nancy, Adams, Douglas J., Gundberg, Caren M., Lifton, Richard P., Carpenter, Thomas O.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Endocrine Society 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817612/
https://ncbi.nlm.nih.gov/pubmed/19952276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-0564
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