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Microglial activation and amyloid deposition in mild cognitive impairment: A PET study

BACKGROUND: Activated microglia may play a role in the pathogenesis of Alzheimer disease (AD) as they cluster around beta-amyloid (Aβ) plaques. They are, therefore, a potential therapeutic target in both AD and its prodrome amnestic mild cognitive impairment (MCI). OBJECTIVE: To characterize in vivo...

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Главные авторы: Okello, A, Edison, P, Archer, H A., Turkheimer, F E., Kennedy, J, Bullock, R, Walker, Z, Kennedy, A, Fox, N, Rossor, M, Brooks, D J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Academy of Neurology 2009
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817573/
https://ncbi.nlm.nih.gov/pubmed/19122031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/01.wnl.0000338622.27876.0d
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